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Antibody and cellular treatments for covid-19
Visual summary of living systematic review and network meta-analysis
© 2021 BMJ Publishing Group Ltd.
Interactive
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View past versions
Certainty in
how beneficial
a treatment is
Higher
Lower
How to read
this diagram
Data sources
Published
Preprints
Upcoming
Trials
Participants
Analysed in review
To be included
in next update
Unpublished
Peer reviewed studies published in medical journals
Draft of research paper shared publicly, but not peer-reviewed yet
Data from clinical trial registries reporting results,
received in correspondence from trial authors,
from conference abstracts, or presentation slides
Research published while preparing the most recent
update, which will be included in the next update
Evidence quality displayed:
High
Moderate
Low
Very low
Standard care
Not different from standard care
Most beneficial
Intermediate benefit
Harmful
Very uncertain
Standard care
Not different from standard care
Most beneficial
Intermediate benefit
Harmful
Very uncertain
No reliable evidence
There are fewer than 100
participants in total for this outcome,
so results are not shown
28
Diammonium
glycyrrhizinate +
lopinavir-ritonavir
Antiviral
Classification:
Moderately promising
Total trials
including
intervention
Total
participants
4928
Diammonium
glycyrrhizinate +
lopinavir-ritonavir
Diammonium
glycyrrhizinate +
lopinavir-ritonavir
versus
Risk difference
Days
1.2
Risk difference
per 1000 people
999
Evidence quality (GRADE score)
Moderate
Network comparison
Indirect comparison
Direct comparison
Remdesivir
Because the evidence for many comparisons and outcomes is very
limited, some of the results obtained in the analysis are implausible.
The effect estimates obtained are extremely large, and the evidence
was classified as very low certainty
To differentiate between plausible and implausible very low
certainty evidence, we do not show the effect estimates and the
grey “direction of effect” circle when the estimates are highly
implausible. Results that are highly implausible should not be used
to inform practice.
When selecting links, the numerical values will not be shown for
implausible results, and will be replaced by a warning symbol.
Implausible results
Relative efficacy
≤ 5 times higher
Ratio-based
outcomes
Absolute time to
event outcomes
Relative efficacy
> 5 times higher
Relative difference
in efficacy ≤ 10 days
Relative difference
in efficacy > 10 days
Last updated
Search date:
All identified research published
before this date has been
included in the diagram
This search has been performed to
identify recently published evidence,
for inclusion in the next analysis
Analysis date:
Latest search
for upcoming
evidence:
Published on
bmj.com:
This diagram summarises how treatments compare to each other and the certainty of the evidence available
Interacting with the diagram
Different outcomes
can be selected in
the drop down
menu to the top
left of the diagram
Comparisons can be
filtered by certainty
of evidence using
checkboxes to the
bottom left
Individual treatments and
comparisons can be selected
to highlight connections and
view numerical values
for efficacy
The width of the links show the
certainty of the evidence, according to
the GRADE rating for that comparison
Very low
Low
Moderate
High
The position of the smaller grey circles between
the treatments shows their comparative effects
Not different
Each of the coloured circles
around the edge of the diagram
represents one treatment . They
are grouped by how promising
the treatment appears, given
the current evidence and its
certainty
Left treatment two or
more times as beneficial
as the right treatment
Right treatment two or
more times as beneficial
as the left treatment
Not different
Left treatment improves the
outcome by ≥ five days or 50
per 1000 patients
Right treatment improves
the outcome by ≥ five days
or 50 per 1000 patients
Ratio based outcomes
Absolute time to event
and risk difference outcomes
Evidence quality
DRAFT